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A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior

This translational project investigates sex-dependent behavioral effects of faecal microbiota transplantation to microbiome-depleted mice from AMD patients (selected based on their aggressive and impulsive traits from Q01), as well as healthy controls. Impulsivity will be assessed via the continuous performance test and responses towards acute threat via the escalated resident intruder test. The goal is to determine the sex-dependent effects of faecal transplantation on selected readouts involved in the transfer of the patient’s phenotype to the mice, such as immune parameters, sex hormones, neuronal activity (and morphology, e.g., neurite outgrowth, spines, etc.), and gene expression (e.g., Rbfox1 from prior studies and novel candidates from C01 and C04).

Andreas Reif

A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior B01: Neurobehavioral effects of repetitive prefrontal transcranial direct current stimulation (tDCS) on pathological aggression Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span Principal investigator Deputy Spokesperson Steering committee member Management board member Goethe University Frankfurt

Andreas Reif is a German Psychiatrist, who received his training at the University Hospital Würzburg, where he also did his residency and later on became Vice Chair.

David Slattery

A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior A08: The metabolic lung-brain axis in aggressive behavior in patients with AMD C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains Q03: Integrated Research Training Group (RTG) Principal investigator Research training group (RTG) committee member Public relations team member Goethe University Frankfurt

Professor David Slattery is interested in understanding of the neurobiology and treatment of stress-related disorders; with an emphasis on mood and anxiety disorders.